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T6812L |
Cyclo(-RGDfK) TFA
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Integrin
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Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM). |
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T6812 |
Cyclo(-RGDfK)
|
Cyclo (-RGDfK) |
Integrin
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Cyclo(-RGDfK) (Cyclo (-RGDfK)) is an effective and specific αvβ3 integrin inhibitor. |
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TP1474 |
LXW7
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Integrin
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LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-pepti... |
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TP1879L1 |
P11 acetate
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Integrin
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P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM). |
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T6813 |
Cyclo(RGDyK) trifluoroacetate
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Cyclo(RGDyK) |
Integrin
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Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. |
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T6657 |
SB273005
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Integrin
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SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. |
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T2494 |
Cilengitide
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EMD 121974 |
Integrin
,
Autophagy
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Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa. |
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TP1459L |
Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
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Integrin
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Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin. |
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TP2148 |
LXW7 TFA (1313004-77-1 free base)
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LXW7 TFA |
Integrin
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LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3 integrin (IC50: 0.68 μM). It increases the phosphorylation... |
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T16085 |
MK-0429
|
L-000845704 |
Others
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MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM). |
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TQ0250 |
CWHM-12
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Integrin
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CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1). |
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TP2390 |
Maraciclatide
|
NC-100692,NC 100692,NC100692 |
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Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin. |
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T8726 |
Cyclo(RGDyK)
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Integrin
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Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. |
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T15584 |
Integrin Antagonists 27
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Others
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Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent. |
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T69460 |
TSRI265
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|
|
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TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo. |
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T11663 |
Integrin-IN-2
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Others
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T68462 |
D-Ornithine lactam
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|
|
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D-Ornithine lactam is a building block. It has been used in the synthesis of hepatitis C virus non-structural protein 5B inhibitors, as well as αVβ3 integrin receptor antagonists. |
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T75724 |
LXW7 TFA
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|
|
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LXW7 TFA, a cyclic peptide encompassing Arg-Gly-Asp (RGD), serves as an inhibitor of integrin αvβ3. It demonstrates high binding affinity towards αvβ3 integrin, evidenced by an IC50 value of 0.68 μM. Additionally, LXW7 T... |
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TP1879 |
HSDVHK-NH2
|
P11 |
|
|
Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic. |
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T6806 |
Cilengitide TFA
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|
Integrin
,
Autophagy
|
|
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2. |
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T10920 |
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
|
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Others
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Arg-Gly-Asp-D-Phe-Val (TFA) has anti-tumor activity and is an inhibitor of integrin αvβ3. |
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T75835 |
HSDVHK-NH2 TFA
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|
|
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HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [2]. |
|
T75990 |
Cyclo(Arg-Gly-Asp-D-Phe-Val)
|
|
|
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Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor with antitumor properties, utilized in the research of acute myeloid leukemia [1]. |
|
T76807 |
Etaracizumab
|
|
|
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Etaracizumab (LM 609), an αvβ3 integrin IgG1 monoclonal antibody, effectively inhibits angiogenesis and melanoma tumor growth, offering a potential avenue for anticancer research [1]. |
|
T74400 |
TC113
|
|
|
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TC113, a Gemcitabine (GEM)-based conjugate incorporating the c(RGDyK) sequence, is internalized by A549 cells via the integrin αvβ3 pathway. It demonstrates significant antiproliferative effects on both WM266.4 and A549 ... |
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TP2098 |
Echistatin
|
Echistatin, α1 isoform |
|
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Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycopro... |
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T78064 |
Synstatin (92-119)
|
SSTN92-119 |
Integrin
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Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and attenuation of angiogenic growth factor activation, specific... |
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T82516 |
E(c(RGDfK))₂
|
|
|
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E(c(RGDfK)) is an αvβ3 integrin-specific binding moiety with tumor-targeting properties, demonstrating increased uptake in human ovarian cancer OVCAR-3 xenograft tumors, suggesting potential utility in cancer research [1... |
|
T75761 |
Gly-Arg-Gly-Asp-Ser TFA
|
GRGDS TFA |
|
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Gly-Arg-Gly-Asp-Ser (TFA), a pentapeptide comprising the cell-binding domain of osteopontin (a glycoprotein), interacts with integrin receptors αvβ3 and αvβ5, exhibiting respective estimated IC50 values of approximately ... |
|
T76068 |
Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
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|
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Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (Cyclo RGDfC) TFA, a cyclic RGD peptide, displays a high affinity for αvβ3 integrin, effectively disrupting cell-integrin interactions. It suppresses pluripotent marker expression in embr... |
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TP1974 |
Obtustatin
|
|
|
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Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chor... |
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T83736 |
RTDLDSLRTYTL TFA
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|
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RTDLDSLRTYTL is a ligand for αVβ6 integrin, exhibiting selective inhibition of fibronectin's binding to αVβ6 integrin with considerably less effect on the interactions between vitronectin and αVβ3 or αVβ5, as well as fib... |
